This symposium is a must for everyone involved in environmental risk assessment and who wants to learn more about the needs and challenges to adapt the latest mechanistic ecological modelling approaches to the different regulatory risk assessment schemes. The symposium will kick off with the regulatory views of EFSA, European Commission and ECHA, covering current practices and outlook and challenges for the implementation of new developments into the risk assessment schemes of the different chemical regulations. This will be followed by a series of presentations by key experts on novel experimental and modelling approaches, as well as successful case studies on how these approaches can inform future environmental risk assessments of chemicals in a regulatory context.
10:00 – 10:05: Welcome (Bart Bosveld, SETAC Europe, Belgium)
10:05 – 10:15: Introduction: Extrapolation of effects across biological levels: challenges to implement scientific approaches in regulation (Paul van den Brink, Wageningen Environmental Research and Wageningen University, Netherlands). View his presentation.
10:15 – 11:45: Session 1: Regulatory Background and Needs of Extrapolation (risk assessments, data requirements, protection goals, extrapolation tools used and tools needed):
- 10:15 – 10:45 Regulatory Background and Needs of Extrapolation for Industrial Chemicals and Biocidal Products (Anna-Maija Nyman, ECHA, Finland). View her presentation.
- 10:45 – 11:15 Plant Protection Products (Miguel Santos, EFSA, Italy). View his presentation.
- 11:15 – 11:45 Data Requirement and Risk Assessment in Pharmaceuticals. Where Can We Use Extrapolation Tools? (Gerd Maack, Federal Environmental Agency (UBA), Germany). View his presentation.
11:45 – 12:00: Poster display and coffee break
12:00 – 13:00: Session 1 (continued)
- 12:00 – 12:20 Needs of Extrapolation Tools in EU Chemical Legislations – A Risk Manager’s View (Georg Streck, European Commission, DG for Internal Market, Industry, Entrepreneurship and SMEs (DG GROW), Belgium)
- 12:20 – 12:40 Scientific Development and Regulatory Needs in ERA: The Relationship Between Hierarchical Levels and Uncertainty (Marco Vighi, IMDEA Water Institute, Spain). View his presentation.
- 12:40 – 13:00 Plenary discussion session 1
13:00 – 14:00: Lunch break
14:00 – 16:00: Session 2: From Sub-Organism to Organism Level
- 14:00 – 14:30 Link Omics Data to TK-TD Parameters, Report from NIMBioS Workshops (Philipp Antczak, University of Liverpool, UK). View his presentation.
- 14:30 – 15:00 Extrapolation Between Species: qAOPs and TK-TD Models (Roman Ashauer, The University of York)
- 15:00 – 15:30 Prediction of Chemical Bioaccumulation and Toxicity to Fish: PBTK-TD Models in Combination with in Vitro Assays (Julita Stadnicka-Michalak, EPFL – Swiss Federal Institute of Technology, Switzerland)
15:30 – 16:00 Plenary discussion session 2
16:00 – 17:30 Poster highlight and drinks
19:30 Symposium dinner
09.00 – 12:00: Session 3: From organism to population to communities and ecosystem level
- 9:00 – 9:30 Population Modelling: Linking Regulatory Standard Data to Specific Protections Goals (Thomas Preuss, Bayer AG, Germany). View his presentation.
- 9:30 – 10:00 Modelling chemical effects on community and ecosystem level (Udo Hommen, Fraunhofer IME, Germany). View his presentation.
- 10:00 – 10:30 From Organism To Population To Communities and Ecosystem Level. A New Approach Based on Ecosystem Services (Jose V. Tarazona, European Food Safety Authority (EFSA)). View his presentation.
- 10:30 – 11:00 Using Models for Linking and Integrating Across Scales: Pros & Cons and Needs (Honeybees Example) (Volker Grimm, Helmholtz Centre for Environmental Research – UFZ, Germany). View his presentation.
- 11:00 – 11:30 Poster display and coffee break
- 11:30 – 12:00 Plenary discussion session 3
12:00 – 13:00: Lunch
13:00 – 15:30: Session 4: Recent examples of implementation of science into regulation
- 13:00 – 13:30 Combining Exposure Assessment and Effect Assessment by TK-TD Models (Andreas Focks, Wageningen Environmental Research, Netherlands). View his presentation.
- 13:30 – 14:00 Implementation of Omics Into Risk Assessment (Bruno Campos, Unilever R&D, UK). View his presentation.
- 14:00 – 14:30 Implementation of Science into Regulations: A Recent Example from the European Union (Jörg Römbke, ECT Oekotoxikologie GmbH, Germany). View his presentation.
14:30 – 15:00 Coffee break
- 15:00 – 15:30 Plenary discussion session 4
15:30 – 16:00: Session 5: Final discussion and conclusions
16:00 End of symposium
P01│ Landscape-level risk assessment for Lemna spp. exposed to plant protection products by spatiotemporally explicit catchment modelling│Stefan Reichenberger, knoell Germany GmbH, Germany
P02│ TK-TD modelling as additional line of evidence in the risk assessment for aquatic macrophytes: chlorotoluron as a case study│Judith Klein, Fraunhofer IME Schmallenberg, Germany
P03│ A comparison between vegetative and reproductive endpoints for two non‑target plant studies with non-crop species in greenhouse and field│Andreas Duffner, Eurofins Agroscience Services Ecotox GmbH, Germany
P04│ Bridging the gap across species by the means of TK-TD modelling│Kim Rakel, Research Institute for Ecosystem Analysis and Assessment (gaiac), Germany
P05│ Effects of atrazine on embryogenesis and larvae development of african catfish, Clarias gariepinus (Burchell, 1822)│Prosper Ashibudike Opute, University of Benin, Nigeria
P06│ Linking exposure and effect of wastewater-derived chemicals in aquatic environment using water quality and toxicokinetic modelling│Maricor Arlos, Eawag & ETH Zürich, Switzerland
P07│From population level effects to community functioning: a network approach│Melanie Hagen-Kissling, Eurofins-Mitox, the Netherlands
P08│ Indicators to evaluate the interaction between bees and their environments using Support Vector Machines│Silvina Niell, Universidad de la República, Uruguay
P09│ Modelling synergistic effects of Pb and pyrene on the toxicokinetics and biochemistry of the marine polychaete Hediste diversicolor│Sarah Bagwell, Bournemouth University, UK
P10│ Modelling the effects of radiation on populations of wildlife│Nele Horemans, Belgian Nuclear Research Centre, Belgium
P11│ Predicting plant community level effects of herbicides based on plant individual level responses: Testing the plant community model IBC-grass with experimental datare│Jette Reeg, University of Potsdam, Germany
P12│ Developing population models for use in environmental risk assessment│Amelie Schmolke, Waterborne Environmental, USA
P13│ Challenges in extrapolation of effects in industrial effluent assessment and management│Mathijs Smit, Shell International, The Netherlands
P14│ The STREAMcom model – Simulating chemical effects on stream macroinvertebrate communities│Andre Gergs, Bayer AG & gaiac, Germany
P15│ Quantification of an Adverse Outcome Pathway by Bayesian network modelling: extrapolation from molecular events to demographic responses in duckweed (Lemna minor)│Jannicke Moe, Norwegian Institute for Water Research, Norway
P16│ Adverse effects of an aquaculture medicine on non-target shrimp populations: extrapolation from laboratory experiments to demographic endpoints by population modelling│Jannicke Moe, Norwegian Institute for Water Research, Norway
P17│ An integrated bioenergetics and TK/TD model of suborganismal and organismal responses of the Atlantic killifish Fundulus heteroclitus exposed to dioxin-like chemicals│Roger Nisbet, University of California Santa Barbara, USA
P18│ Incorporating transgenerational epigenetic inheritance into ecological risk assessment frameworks│Jennifer L.A. Shaw, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
P21│ Ecorelevance – improving ecological realism in metal risk assessment: development, validation and application of population models for population-level effect assessment│Karel Vlaeminck, Ghent University & Arche Consulting, Belgium
P22│ Estimating realistic biological variability in Dynamic Energy Budget model parameters of a copepod │Josef Koch, Ghent University, Belgium